Patients in EMIAT qualified with ejection fraction 40 and those randomized to amiodarone received fixed doses of 200 mg day. Therefore, at the inception of and during amiodarone treatment, pacing and defibrillation thresholds should be assessed. The effects of food upon the bioavailability of Cordarone have been studied in 30 healthy subjects who received single 600-mg dose immediately after consuming high-fat meal and following an overnight fast. In addition to the interactions noted above, chronic weeks oral Cordarone administration impairs metabolism of phenytoin, dextromethorphan, and methotrexate. There have been postmarketing reports of thyroid nodules thyroid cancer in patients treated with Cordarone. Therefore, when Cordarone therapy is initiated, cordarone kjope cordarone baseline chest X-ray and pulmonary-function tests, including diffusion capacity, should be performed.